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1993;12(3):534544. 5 1 0. 4 Cytoplasmic Mechanisms of Post-transcriptional Control 519 miRNA precursor Double-stranded 5' p OR Dicer Double-stranded RNA OH 3' p 5' OH 3' misiRNA RISC miRNA function 3' OH 5' p FPO 3' OH p 5' siRNA function An 3' OH Perfect base pairing; target cleavage p 5' An Incomplete base pairing; translation repression FIGURE 12-27 Model for miRNA translational repression and RNA interference mediated by the RNA-induced interfering complex (RISC).
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