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Vercellini P, Aimi G, Panazza S, et al. Natl. 25 D 51. I am indebted to them, and I am also quite proud to count them as colleagues. 935 0. For some interfaces electrostatic interac- tions help steer the ligand onto the correct docking orientationlocation. The most common reaction of carbanions is combination with a positive species, usually a proton, or with another species that has an empty orbital in its outer shell (a Lewis acidbase reaction): RY RY Carbanions may also form a bond with a carbon that already has four bonds, by displacing one of the four groups (SN2 reaction, see Chapter 10): RCX RCX Like carbocations, carbanions can also react in ways in which they are converted to species that are still not neutral molecules.
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